Deep brain stimulation for severe obsessive compulsive disorder: efficacy and mechanisms of ventral striatum and subthalamic nucleus targets

Study Details

The overarching study aim is to establish the potential of deep brain stimulation (DBS) for people with obsessive compulsive disorder (OCD) who have failed to respond to the best currently available medical treatment and who are significantly disabled by their symptoms. Previous studies indicate that DBS of the ventral striatum/ventral capsule (VS/VC) and the subthalamic nucleus (STN) are effective for OCD. About two-thirds showed clear improvement but remained moderately symptomatic. The main objective of this study is to investigate whether this efficacy can be improved by determining:
i. Whether DBS at both sites is more efficacious than DBS at either site alone for the alleviation of all symptom dimensions of OCD;
ii. The different mechanisms of action of DBS at the two brain sites which explain why DBS at both sites is better than each site alone;
iii. Whether adjunctive cognitive behavioural therapy improves DBS-mediated clinical outcomes.

Primary Investigator:

Professor Eileen Joyce, UCL, London


National Services Scotland

Advanced Interventions Service
Area 7, Level 6
South Block
Ninewells Hospital and Medical School
Dundee, DD1 9SY. UK.
Tel: +44 (0)1382 496233

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