This study will use Diffusion Tensor Imaging (DTI) and functional magnetic resonance imaging (fMRI) to relate neuropsychological performance and clinical status (symptoms) with measures of white matter integrity and grey matter function in 'emotional-processing-relevant' brain networks. This will lead to a greater understanding of the consequences and side-effects of neurosurgery. Using DTI in addition to fMRI will help to map lesion topography and subsequent effects on communicating white matter tracts with great precision, helping to develop our understanding of the functional architecture of depression. This will help guide the development of novel and more effective treatment strategies.
Professor Douglas Steele