Diffusion Tensor and Functional Imaging of Chronic Treatment Refractory Depression and Neurosurgical Treatments

Study Details

This study will use Diffusion Tensor Imaging (DTI) and functional magnetic resonance imaging (fMRI) to relate neuropsychological performance and clinical status (symptoms) with measures of white matter integrity and grey matter function in 'emotional-processing-relevant' brain networks. This will lead to a greater understanding of the consequences and side-effects of neurosurgery. Using DTI in addition to fMRI will help to map lesion topography and subsequent effects on communicating white matter tracts with great precision, helping to develop our understanding of the functional architecture of depression. This will help guide the development of novel and more effective treatment strategies.

Primary Investigator:

Professor Douglas Steele


National Services Scotland

Advanced Interventions Service
Area 7, Level 6
South Block
Ninewells Hospital and Medical School
Dundee, DD1 9SY. UK.
Tel: +44 (0)1382 496233

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